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| See also: Homoeopathic Remedies for Morning Sickness | ||
Reliable and relatively consistent scientific data showing a substantial health benefit. Contradictory, insufficient, or preliminary
studies suggesting a health benefit or minimal health benefit. For an herb, supported by traditional use but
minimal or no scientific evidence. For a supplement, little scientific support and/or minimal
health benefit. | ||
Symptoms include nausea, vomiting, fatigue, lightheadedness, and dizziness during the early stages of pregnancy. Women with morning sickness may be particularly sensitive to certain odours and foods. However, eating small amounts of a particular food may relieve their symptoms.
No over the counter drugs are FDA-approved for the treatment of morning sickness. However, drugs such as dimenhydrinate (Dramamine®), diphenhydramine (Benadryl®), and meclizine (Bonine®) have been used.
Prescription medications used include prochlorperazine (Compazine®), ondansetron (Zofran®), meclizine (Antivert®), promethazine (Phenergan®), and metoclopramide (Reglan®).
Healthcare practitioners typically recommend that women with morning sickness drink plenty of fluids and try to eat whatever they can, regardless of its nutritional value.
Some doctors recommend that women with morning sickness eat dry crackers upon waking. Drinking liquids and eating solid foods at separate times may be helpful as well.
In a Harvard University study, women with a high intake of saturated fat (found mainly in meat and dairy) during the year prior to pregnancy had a much higher risk of severe morning sickness than did women eating less saturated fat. An increase in saturated fat intake of 15 grams per day (the equivalent of a four-ounce cheeseburger or three cups of whole milk) was associated with a greater than threefold increase in the risk of developing morning sickness.2
In two double-blind trials, supplementation with vitamin B6 (10 or 25 mg three times per day) significantly reduced the severity of morning sickness.3 4
Vitamin K and vitamin C, taken together, may provide relief of symptoms for some women. In one study, 91% of women who took 5 mg of vitamin K and 25 mg of vitamin C per day reported the complete disappearance of morning sickness within three days.5 However, most doctors use higher amounts of vitamin C (500 to 1,000 mg per day).
In a preliminary study done in the 1930s, eight women suffering from nausea and vomiting during the first trimester (13 weeks) of pregnancy received large amounts of oral adrenal cortex extract. In most cases, vomiting stopped after three to four days.6 In a follow-up study, women with nausea and vomiting of pregnancy received adrenal cortex extract, usually by injection at first, followed by oral administration. More than 85% of the women were completely relieved of the problem or showed definite improvement.7 Since no safety data exist for use during pregnancy, adrenal extract should not be used in these situations unless supervised by a doctor.
Ginger is well-known for alleviating nausea and improving digestion. One gram of encapsulated ginger powder was used in one study to reduce the severe nausea and vomiting associated with hyperemesis gravidarum.8 This condition is potentially life-threatening and should only be treated by a qualified healthcare professional.
Because ginger contains some compounds that cause chromosomal mutation in the test tube, some doctors are concerned about the safety of using ginger during pregnancy. However, the available clinical research, combined with the fact that ginger is widely used in the diets of many cultures, suggests that prudent use of ginger for morning sickness is probably safe in amounts up to 1 gram per day.9
A controlled trial found that acupuncture significantly reduced symptoms in women with hyperemesis gravidarum, a severe form of nausea and vomiting of pregnancy that usually requires hospitalisation.10 Treatment consisted of acupuncture at a single point on the forearm three times daily for two consecutive days. Acupressure (in which pressure, rather than needles, is used to stimulate acupuncture points) has also been found in several preliminary trials to be mildly effective in the treatment of nausea and vomiting of pregnancy.11 12 13
1. Chan NN. Thyroid function in hyperemesis gravidarum. Lancet 1999;353:2243 [letter].
2. Signorello LB, Harlow BL, Wang SP, Erick MA. Saturated fat intake and the risk of severe hyperemesis gravidarum. Am J Epidemiol 1996;143 (11 Suppl):S25 [abstract # 97].
3. Sahakian V, Rouse D, Sipes S, et al. Vitamin B6 is effective therapy for nausea and vomiting of pregnancy: a randomized, double-blind placebo-controlled study. Obstet Gynecol 1991;78:33–6.
4. Vutyavanich T, Wongtra-ngan S, Ruangsri R. Pyridoxine for nausea and vomiting of pregnancy: a randomized, double blind, placebo-controlled trial. Am J Obstet Gynecol 1995;173:881–4.
5. Merkel RL. The use of menadione bisulfite and ascorbic acid in the treatment of nausea and vomiting of pregnancy. Am J Obstet Gynecol 1952;64:416–8.
6. Kemp WN. Hyperemesis gravidarum treated as a temporary adrenal cortex deficiency. Can Med Assoc J 1933;28:389–91.
7. Kemp WN. The vomiting of pregnancy treated as a temporary relative insufficiency of maternal corticoadrenal function. Med Rec 1934;140:239–41.
8. Fischer-Rasmussen W, Kjaer SK, Dahl C, Asping U. Ginger treatment of hyperemesis gravidarum. Eur J Obstet Gynecol Reprod Biol 1990;38:19–24.
9. Fulder S, Tenne M. Ginger as an anti-nausea remedy in pregnancy and the issue of safety. HerbalGram 1996;38:47–50.
10. Carlsson CPO, Axemo P, Bodin A, et al. Manual acupuncture reduces hyperemesis gravidarum: a placebo-controlled, randomized, single-blind, crossover study. J Pain Symptom Manage 2000;20:273–9.
11. Stainton MC, Neff EJ. The efficacy of SeaBands for the control of nausea and vomiting in pregnancy. Health Care Women Int 1994;15:563–75.
12. Belluomini J, Litt RC, Lee KA, Katz M. Acupressure for nausea and vomiting of pregnancy: a randomized, blinded study. Obstet Gynecol 1994;84:245–8.
13. Hyde E. Acupressure therapy for morning sickness. A controlled clinical trial. J Nurse Midwifery 1989;34:171–8.
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