Shop products for Cisapride 
Cisapride is a gastrointestinal stimulant drug used to treat people with night-time heartburn due to reflux of stomach acid into the oesophagus. It is also used to increase movement of gastrointestinal contents in conditions of lack of spontaneous gastrointestinal movement.
Summary of
Interactions with Vitamins, Herbs, and Foods
In some cases, an herb or supplement may appear in more than one category, which may seem
contradictory. For clarification, read the full article for details about the summarized
interactions.
 Avoid: Reduced drug absorption/bioavailability—Avoid
these supplements when taking this medication since the supplement may decrease the absorption
and/or activity of the medication in the body. |
Tobacco |
| Avoid: Adverse interaction—Avoid these supplements
when taking this medication because taking them together may cause undesirable or dangerous
results. |
Grapefruit juice Red wine |
| Depletion or interference |
None known |
| Side effect reduction/prevention |
None known |
| Supportive interaction |
None known |
An asterisk (*) next to an item in the summary indicates that the interaction is supported only by weak, fragmentary, and/or contradictory scientific evidence.
Interactions with Foods and Other Compounds
Alcohol
Alcohol consumption is associated with night-time heartburn and may interfere with cisapride
therapy.1 Alcohol causes sleepiness, and cisapride may intensify this
effect,2 increasing the risk of accidental injury. Ingestion of red wine along with
cisapride may also increase blood levels of the drug in some individuals, potentially
increasing its side effects.3 People taking cisapride should avoid alcohol.
Tobacco
Smoking is associated with night-time heartburn and may interfere with cisapride
therapy.4 Smokers taking cisapride may benefit from reducing or quitting
smoking.
Grapefruit juice
In a study of healthy males, ingestion of 250 ml (about one cup) of grapefruit juice along
with cisapride increased the peak blood level of the drug by an average of 68%.5 It
is not known whether consuming grapefruit juice at a separate time of the day would affect
blood levels of cisapride. As this interaction could potentially increase the side effects of
cisapride, individuals taking cisapride should avoid grapefruit and its juice.
References
1. Threlkeld DS, ed. Gastrointestinal Drugs, GI Stimulants, Cisapride. In Facts and Comparisons Drug Information. St. Louis, MO: Facts and Comparisons, Nov 1998, 308b–8c.
2. Threlkeld DS, ed. Gastrointestinal Drugs, GI Stimulants, Cisapride. In Facts and Comparisons Drug Information. St. Louis, MO: Facts and Comparisons, Nov 1998, 308b–8c.
3. Offman EM, Freeman DJ, Dresser GK, et al. Red wine-cisapride interaction: comparison with grapefruit juice. Clin Pharmacol Ther 2001;70:17–23.
4. Threlkeld DS, ed. Gastrointestinal Drugs, GI Stimulants, Cisapride. In Facts and Comparisons Drug Information. St. Louis, MO: Facts and Comparisons, Nov 1998, 308b–8c.
5. Offman EM, Freeman DJ, Dresser GK, et al. Red wine-cisapride interaction: comparison with grapefruit juice. Clin Pharmacol Ther 2001;70:17–23.
