Shop products for Glyburide 
Also indexed as: Albert Glyburide®, Apo-Glyburide®, Calabren®, Daonil®, Diabetamide®, Diabeta®, Euglucon®, Gen-Glybe®, Glibenclamide, Gliken®, Glynase Prestab®, Glynase™, Libanil®, Malix®, Micronase®, Novo-Glyburide®, Nu-Glyburide®, PMS-Glyburide®, Pres Tab®, Semi-Daonil®
Glyburide is a sulfonylurea drug used to lower blood sugar levels in people with type 2 (non-insulin-dependent) diabetes. Maintaining normal blood sugar levels helps reduce health problems associated with diabetes. People with diabetes should consult with their doctor before starting or stopping any form of treatment including drug therapy, herbal products, supplements, and others.
Consumption of a high-fibre diet and/or supplementation with nutrients such as chromium, biotin, vitamin E, and others or herbs such as Gymnema sylvestre will often improve blood-sugar control in diabetics. In such cases, the amount of blood sugar-lowering drugs may need to be reduced in order to avoid a hypoglycaemic reaction. Anyone taking medication for diabetes should consult the prescribing physician before making dietary changes or taking nutrients or herbs that are designed to lower blood-sugar levels.
Summary of
Interactions with Vitamins, Herbs, and Foods
In some cases, an herb or supplement may appear in more than one category, which may seem
contradictory. For clarification, read the full article for details about the summarized
interactions.
 May be Beneficial: Supportive
interaction—Taking these supplements may support or otherwise help your medication
work better. |
Aloe vera* |
 Avoid: Adverse interaction—Avoid these supplements
when taking this medication because taking them together may cause undesirable or dangerous
results. |
Chromium* Ginkgo biloba |
 Check: Other—Before taking any of these supplements
or eating any of these foods with your medication, read this article in full for details. |
Biotin Gymnema sylvestre Vitamin E |
| Depletion or interference |
None known |
| Side effect reduction/prevention |
None known |
| Reduced drug absorption/bioavailability |
None known |
An asterisk (*) next to an item in the summary indicates that the interaction is supported only by weak, fragmentary, and/or contradictory scientific evidence.
Interactions with Herbs
Aloe (Aloe
vera)
One single-blind study in Thailand reported that combining 1 Tbsp (15 ml) of aloe juice twice
daily with glyburide significantly improved blood sugar and lipid levels in people with
diabetes, compared with placebo.1 Previously, glyburide by itself had not
effectively controlled the diabetes in the people in this study.
Ginkgo
biloba*
In a preliminary trial, administration of Ginkgo biloba extract (120 mg per day) for
three months to patients with type 2 diabetes who were taking oral anti-diabetes medication
resulted in a significant worsening of glucose tolerance. Ginkgo did not impair glucose
tolerance in individuals whose diabetes was controlled by diet.2 Individuals taking
oral anti-diabetes medication should consult a doctor before taking Ginkgo
biloba.
Interactions with Foods and Other Compounds
Food
Glyburide may be taken with food to avoid gastrointestinal (GI) upset.3 Effective
treatment of type 2 diabetes with glyburide includes adherence to recommended dietary
guidelines.
Alcohol
Alcohol consumption may interfere with blood-sugar control during glyburide
therapy.4 Alcohol may interact with glyburide, causing facial flushing, headache,
light-headedness, nausea, breathlessness, and other symptoms.5 People taking
glyburide should avoid alcohol.
References
1. Bunyapraphatsara N, Yongchaiyudha S, Rungpitarangsi V, Chokechaijaroenporn O. Antidiabetic activity of Aloe vera L. juice. II. Clinical trial in diabetes mellitus patients in combination with glibenclamide. Phytomed 1996;3:245–8.
2. Kudolo GB. The effect of 3-month ingestion of Ginkgo biloba extract (EGb 761) on pancreatic beta-cell function in response to glucose loading in individuals with non-insulin-dependent diabetes mellitus. J Clin Pharmacol 2001;41:600–11.
3. Threlkeld DS, ed. Hormones, Antidiabetic Agents, Sulfonylureas. In Facts and Comparisons Drug Information. St. Louis, MO: Facts and Comparisons, Jun 1992, 130m.
4. Threlkeld DS, ed. Hormones, Antidiabetic Agents, Sulfonylureas. In Facts and Comparisons Drug Information. St. Louis, MO: Facts and Comparisons, Jun 1992, 130m.
5. Threlkeld DS, ed. Hormones, Antidiabetic Agents, Sulfonylureas. In Facts and Comparisons Drug Information. St. Louis, MO: Facts and Comparisons, Jun 1992, 130m.
