Shop products for Heparin 
Also indexed as: Calciparine®, Hepalean®, Heparin Leo®, Minihep Calcium®, Minihep®, Monoparin Calcium®, Monoparin®, Multiparin®, Pump-Hep®, Unihep®, Uniparin Calcium®, Uniparin Forte®
Heparin is a natural product, available by prescription, which is used as an anticoagulant (slows the rate of blood clot formation). Blood clots can cause severe and life-threatening problems. Heparin is used to prevent formation of blood clots (after surgery and in other settings) and in circumstances to help dissolve blood clots already formed (deep vein thrombosis, pulmonary embolism, and other situations involving excessive blood clotting).
Summary of
Interactions with Vitamins, Herbs, and Foods
In some cases, an herb or supplement may appear in more than one category, which may seem
contradictory. For clarification, read the full article for details about the summarized
interactions.
 May be Beneficial: Depletion or
interference—The medication may deplete or interfere with the absorption or
function of the nutrient. Taking these nutrients may help replenish them. |
Vitamin D |
 Avoid: Adverse interaction—Avoid these supplements
when taking this medication because taking them together may cause undesirable or dangerous
results. |
Digitalis* Dong quai* Fenugreek* Ginger* Ginkgo biloba* Horse chestnut* Red clover* Reishi Sweet clover* Sweet woodruff* |
 Check: Other—Before taking any of these supplements
or eating any of these foods with your medication, read this article in full for details. |
Potassium |
| Side effect reduction/prevention |
None known |
| Supportive interaction |
None known |
| Reduced drug absorption/bioavailability |
None known |
An asterisk (*) next to an item in the summary indicates that the interaction is supported only by weak, fragmentary, and/or contradictory scientific evidence.
Interactions with Dietary Supplements
Potassium
Heparin therapy may cause hyperkalemia (abnormally high potassium levels).1
2 Potassium supplements, potassium-containing salt substitutes (No Salt®, Morton
Salt Substitute®, and others), and even high-potassium foods (primarily fruit) should be avoided by persons on heparin therapy, unless
directed otherwise by their doctor.
Vitamin D
Heparin may interfere with activation of vitamin D in the body.3 Osteoporosis (thinning of the bone) has been reported in
patients who received high amounts of heparin for several months.4 Osteopenia
(decreased bone density) has been reported in women who received heparin therapy during pregnancy.5 6
Interactions with Herbs
Digitalis (Digitalis purpurea)
Digitalis refers to a group of plants commonly called foxglove, which contains chemicals
related to the drug digoxin. Digitalis may interfere with
the anticoagulant action of heparin, reducing its action.7 Digitalis should only be
used under the direct supervision of a doctor trained in its use.
Ginger
Ginger has been shown to reduce platelet stickiness in test tubes. Although there are no
reports of interactions with anticoagulant drugs, people should consult a healthcare
professional if they are taking an anticoagulant and wish to use ginger.8
Ginkgo
biloba
Ginkgo extracts may reduce the ability of platelets to stick together, possibly increasing the
tendency toward bleeding.9 Standardized extracts of ginkgo have been associated
with two cases of spontaneous bleeding, although the ginkgo extracts were not definitively
shown to be the cause of the problem.10 11 People taking heparin should
consult with a physician knowledgeable about botanical medicines if they are considering
taking ginkgo.
Herbs containing coumarin-derivatives
Although there are no specific studies demonstrating interactions with anticoagulants, the
following herbs contain coumarin-like substances that may interact with heparin and could
conceivably cause bleeding.12 These herbs include
dong quai, fenugreek, horse chestnut, red
clover, sweet clover, and sweet woodruff. People should consult a healthcare professional
if they’re taking an anticoagulant and wish to use one of these herbs.
Reishi(Ganoderma
lucidum)
As it may increase bleeding time, reishi is not recommended for those taking anticoagulant
(blood-thinning) medications.13
Interactions with Foods and Other Compounds
Alcohol
Alcohol consumption during heparin therapy may increase the risk of serious
bleeding.14 It is important for people receiving heparin to avoid alcohol during
the entire course of heparin therapy.
References
1. Threlkeld DS, ed. Blood Modifiers, Anticoagulants, Heparin. In Facts and Comparisons Drug Information. St. Louis, MO: Facts and Comparisons, Jun 1997, 87a–7f.
2. Perazella MA. Drug-induced hyperkalemia: Old culprits and new offenders. Am J Med 2000;109:307–14 [review].
3. Aarskog D, Aksens L, Markestad TK, et al. Heparin induced inhibition of 1,25-dihydroxyvitamin D formation. Am J Obstet Gynecol 1984;148:1141–2.
4. Majerus PW, Broze GJ Jr, Miletich JP, Tollefsen DM. Anticoagulant, thrombolytic, and antiplatelet drugs. In Goodman and Gilman’s The Pharmacological Basis of Therapeutics, 9th ed. New York: McGraw-Hill 1996, 1346.
5. Wise PH, Hall AS. Heparin induced osteopenia in pregnancy. BMJ 1980;281:110–1.
6. Haram K, Hervig T, Thordarson H, Aksnes L. Osteopenia caused by heparin treatment in pregnancy. Acta Obstet Gynecol Scand 1993;72:674–5.
7. Threlkeld DS, ed. Blood Modifiers, Anticoagulants, Heparin. In Facts and Comparisons Drug Information. St. Louis, MO: Facts and Comparisons, Jun 1997, 87a–7f.
8. Newall CA, Anderson LA, Phillipson JD. Herbal Medicines: A Guide for Health-Care Professionals. London: The Pharmaceutical Press, 1996, 135–7.
9. Kleijnen J, Knipschild P. Ginkgo biloba. Lancet 1992;340:1136–9.
10. Rosenblatt M, Mindel J. Spontaneous hyphema associated with ingestion of Ginkgo biloba in whom bleeding occurred after the addition of ginkgo.
11. Mathews MK. Association of Ginkgo biloba with intracerebral hemorrhage. Neurology 1998;50:1934.
12. Miller LG, Murray WJ, eds. Herbal Medicinals: A Clinician’s Guide. New York: Pharmaceutical Products Press, 1999, 313–5.
13. Brinker F. Herb Contraindications and Drug Interactions. Sandy, OR: Eclectic Medical Publications, 1998,166–9.
14. Holt GA. Food & Drug Interactions. Chicago: Precept Press, 1998, 127.
