Shop products for Ketoprofen 
Also indexed as: Apo-Keto®, Fenoket®, Jomethid XL®, Ketil CR®, Ketocid®, Ketoprofen CR®, Ketotard® 200XL, Ketovail®, Ketozip XL®, Larafen CR®, Novo-Keto®, Nu-Ketoprofen®, Orafen®, Orudis®, Oruvail®, Rhodis®, Rhovail®
Ketoprofen is used to treat rheumatoid arthritis, osteoarthritis, and ankylosing spondylitis. It is in a class of medications known as non-steroidal anti-inflammatory drugs (NSAIDs).
Summary of
Interactions with Vitamins, Herbs, and Foods
In some cases, an herb or supplement may appear in more than one category, which may seem
contradictory. For clarification, read the full article for details about the summarized
interactions.
 May be Beneficial: Depletion or
interference—The medication may deplete or interfere with the absorption or
function of the nutrient. Taking these nutrients may help replenish them. |
Lithium* |
 Avoid: Reduced drug absorption/bioavailability—Avoid
these supplements when taking this medication since the supplement may decrease the absorption
and/or activity of the medication in the body. |
Willow* |
| Avoid: Adverse interaction—Avoid these supplements
when taking this medication because taking them together may cause undesirable or dangerous
results. |
Lithium* White willow* |
| Side effect reduction/prevention |
None known |
| Supportive interaction |
None known |
An asterisk (*) next to an item in the summary indicates that the interaction is supported only by weak, fragmentary, and/or contradictory scientific evidence.
Interactions with Dietary Supplements
Lithium
Lithium is a mineral that may be present in some supplements and is also used in large amounts
to treat mood disorders such as manic-depression. Research has shown that non-steroidal anti-inflammatory drugs may increase blood levels of
lithium,1 resulting in side effects such as
diarrhoea, nausea, muscle weakness, and lack of coordination. Though there is no research
available to show that ketoprofen increases lithium blood levels, until more information is
available, people taking ketoprofen should talk with their healthcare practitioner before
supplementing with lithium.
Interactions with Herbs
Willow (Salix
alba)
Willow bark contains salicin, which is related to aspirin.
Both salicin and aspirin produce anti-inflammatory effects after they have been converted to
salicylic acid in the body. The interaction between salicylic acid and ketoprofen is complex.
While it may enhance the effectiveness of ketoprofen, salicylic acid also speeds its
elimination from the body.2 Consequently, people taking ketoprofen should avoid
herbal products that contain willow bark.
Interactions with Foods and Other Compounds
Food
Ketoprofen may cause stomach upset and should therefore be taken with food.3
Calories and Fat
Taking a slow-release form of ketoprofen with low-fat, low-calorie food may increase the
absorption of the drug, compared with taking it with a high-fat, high-calorie
meal.4 Individuals who eat a diet high in calories and fat may require an
adjustment in the daily amount of ketoprofen taken or may experience greater benefit by
switching to a low-fat, low-calorie diet. Consult a qualified professional about matching
ketoprofen dosage with dietary fat and calorie intake.
References
1. Sifton DW, ed. Physicians Desk Reference. Montvale, NJ: Medical Economics Company, Inc., 2000, 3285–8.
2. Sifton DW, ed. Physicians Desk Reference. Montvale, NJ: Medical Economics Company, Inc., 2000, 3285–8.
3. Sifton DW, ed. Physicians Desk Reference. Montvale, NJ: Medical Economics Company, Inc., 2000, 3285–8.
4. Le Liboux A, Teule M, Frydman A, et al. Effect of diet on the single- and multiple-dose pharmacokinetics of sustained-release ketoprofen. Eur J Clin Pharmacol 1994;47:361–6.
