Shop products for Potassium Chloride 
Potassium chloride is a prescription drug used to replace potassium in people with low blood levels of potassium, to prevent potassium depletion in specific diseases or resulting from specific drug therapies, and to help lower mild high blood pressure in some people. Potassium chloride is also available without prescription in some supplements and in salt substitutes found in grocery stores. While potassium depletion is a health risk, high levels of potassium are also associated with health risks. Potassium-containing drugs should be used only under medical supervision. The potassium found in fruit is both safe and healthful for most people, except those taking potassium-sparing diuretic drugs and individuals with kidney failure.
Summary of
Interactions with Vitamins, Herbs, and Foods
In some cases, an herb or supplement may appear in more than one category, which may seem
contradictory. For clarification, read the full article for details about the summarized
interactions.
 Check: Other—Before taking any of these supplements
or eating any of these foods with your medication, read this article in full for details. |
Digitalis Salt substitutes |
| Depletion or interference |
None known |
| Side effect reduction/prevention |
None known |
| Supportive interaction |
None known |
| Reduced drug absorption/bioavailability |
None known |
| Adverse interaction |
None known |
An asterisk (*) next to an item in the summary indicates that the interaction is supported only by weak, fragmentary, and/or contradictory scientific evidence.
Interactions with Dietary Supplements
Salt substitutes
Salt substitutes (No Salt®, Salt Substitute®, Lite Salt®, and others) contain
potassium chloride in place of sodium chloride. They are used by people on sodium-restricted diets. When used in moderation, they are a
more healthful choice for many people compared with using regular table salt. However, people
taking potassium chloride drug products should consult with their prescribing doctor before
using salt substitutes1 or even eating large amounts of high-potassium foods
(primarily fruit).
Interactions with Herbs
Digitalis (Digitalis lanata, Digitalis
purpurea)
Digitalis refers to a family of plants commonly called foxglove that contain digitalis
glycosides, chemicals with actions and toxicities similar to the prescription drug digoxin. Low serum potassium increases the risk of digitalis
toxicity.2 People using digitalis-containing products should have their potassium
status monitored by the healthcare professional overseeing the digitalis therapy.
Interactions with Foods and Other Compounds
Food
Potassium chloride drugs should be taken after meals to avoid stomach upset.3
Potassium-containing salt substitutes, however, are meant to be taken with food. Tablets
should be swallowed whole and chewing or crushing should be avoided.4 Liquid,
powder, and effervescent potassium chloride products may be dissolved in a glass of cold water
or juice to mask the unpleasant flavour.5
References
1. Threlkeld DS, ed. Nutritional Products, Minerals and Electrolytes, Oral, Potassium Replacement Products. In Facts and Comparisons Drug Information. St. Louis, MO: Facts and Comparisons, Jul 1992, 15–6c.
2. Threlkeld DS, ed. Nutritional Products, Minerals and Electrolytes, Oral, Potassium Replacement Products. In Facts and Comparisons Drug Information. St. Louis, MO: Facts and Comparisons, Jul 1992, 15–6c.
3. Threlkeld DS, ed. Nutritional Products, Minerals and Electrolytes, Oral, Potassium Replacement Products. In Facts and Comparisons Drug Information. St. Louis, MO: Facts and Comparisons, Jul 1992, 15–6c.
4. Threlkeld DS, ed. Nutritional Products, Minerals and Electrolytes, Oral, Potassium Replacement Products. In Facts and Comparisons Drug Information. St. Louis, MO: Facts and Comparisons, Jul 1992, 15–6c.
5. Threlkeld DS, ed. Nutritional Products, Minerals and Electrolytes, Oral, Potassium Replacement Products. In Facts and Comparisons Drug Information. St. Louis, MO: Facts and Comparisons, Jul 1992, 15–6c.
