Shop products for Sucralfate 
Also indexed as: Antipepsin®, Apo-Sucralfate®, Carafate®, Novo-Sucralate®, Nu-Sucralfate®, Sulcrate®
Sucralfate is used to treat intestinal ulcers, and it is a type of drug known as a polysaccharide antipeptic.
Summary of
Interactions with Vitamins, Herbs, and Foods
In some cases, an herb or supplement may appear in more than one category, which may seem
contradictory. For clarification, read the full article for details about the summarized
interactions.
 May be Beneficial: Depletion or
interference—The medication may deplete or interfere with the absorption or
function of the nutrient. Taking these nutrients may help replenish them. |
Calcium Phosphorus |
| Side effect reduction/prevention |
None known |
| Supportive interaction |
None known |
| Reduced drug absorption/bioavailability |
None known |
| Adverse interaction |
None known |
An asterisk (*) next to an item in the summary indicates that the interaction is supported only by weak, fragmentary, and/or contradictory scientific evidence.
Interactions with Dietary Supplements
Calcium
Slight increases in blood calcium levels may occur in people taking sucralfate, which could be
aggravated by calcium supplementation.1 Therefore, people taking calcium
supplements and sucralfate should have their blood calcium levels monitored by their
healthcare practitioner and may need to avoid calcium supplementation.
Phosphorus
People taking sucralfate may develop lower than normal blood levels of phosphorus.2
A 42-year-old woman who took sucralfate for two weeks experienced bone pain that was caused by
low phosphorus levels. The bone pain disappeared after she stopped taking the drug and began
supplementing with phosphorus.3 Individuals taking sucralfate should have their
blood phosphorus levels monitored regularly by their healthcare practitioner and may need to
take supplemental phosphorus.
References
1. Vucelic B, Hadzic N, Gragas J, Puretic Z. Changes in serum phosphorus, calcium, and alkaline phosphatase due to sucralfate. Int J Clin Pharmacol Ther Toxicol 1986;24:93–6.
2. Vucelic B, Hadzic N, Gragas J, Puretic Z. Changes in serum phosphorus, calcium, and alkaline phosphatase due to sucralfate. Int J Clin Pharmacol Ther Toxicol 1986;24:93–6.
3. Chines A, Pacifici R. Antacid and sucralfate-induced hypophosphatemic osteomalacia: a case report and review of the literature. Calcif Tissue Int 1990;47:291–5.
