Shop products for Tramadol 
Also indexed as: Dromadol SR®, Tramake Insts®, Tramake®, Ultram®, Zamadol SR®, Zamadol®, Zydol SR®, Zydol XL®, Zydol®
Tramadol is a drug, unrelated to nonsteroidal anti-inflammatory drugs (NSAIDs) or opiates, used to relieve moderate to moderately severe pain.
Summary of
Interactions with Vitamins, Herbs, and Foods
In some cases, an herb or supplement may appear in more than one category, which may seem
contradictory. For clarification, read the full article for details about the summarized
interactions.
 Avoid: Adverse interaction—Avoid these supplements
when taking this medication because taking them together may cause undesirable or dangerous
results. |
5-Hydroxytryptophan (5-HTP)* L-tryptophan* |
| Depletion or interference |
None known |
| Side effect reduction/prevention |
None known |
| Supportive interaction |
None known |
| Reduced drug absorption/bioavailability |
None known |
An asterisk (*) next to an item in the summary indicates that the interaction is supported only by weak, fragmentary, and/or contradictory scientific evidence.
Interactions with Dietary Supplements
5-Hydroxytryptophan (5-HTP) and
L-tryptophan
Tramadol, which blocks serotonin reuptake in the brain, has been associated with two cases of
serotonin syndrome.1 2 5-HTP and L-tryptophan are converted to serotonin
in the brain. While no interactions have yet been reported with tramadol and 5-HTP or
L-tryptophan, taking 5-HTP or L-tryptophan with tramadol may increase the risk of
tramadol-induced side effects, including serotonin syndrome.
Interactions with Foods and Other Compounds
Food
Tramadol may be taken with or without food.3
Alcohol
Tramadol may impair mental ability and physical coordination.4 Alcohol may
intensify these effects and increase the risk of accidental injury. People taking tramadol are
cautioned to avoid alcohol.
References
1. Mason BJ, Blackburn KH. Possible serotonin syndrome associated with tramadol and sertraline coadministration. Ann Pharmacother 1997;31:175–7.
2. Hernandez AF, Montero MN, Pla A, Villanueva E. Fatal moclobemide overdose or death caused by serotonin syndrome? J Forensic Sci 1995;40:128–30.
3. Threlkeld DS, ed. Central Nervous System Drugs, Central Analgesics, Tramadol HCl. In Facts and Comparisons Drug Information. St. Louis, MO: Facts and Comparisons, May 1995, 246b–6f.
4. Threlkeld DS, ed. Central Nervous System Drugs, Central Analgesics, Tramadol HCl. In Facts and Comparisons Drug Information. St. Louis, MO: Facts and Comparisons, May 1995, 246b–6f.
